The Jacksonville Jaguars (1-0) face the Cincinnati Bengals (1-0) in a Week 2 AFC showdown at Paycor Stadium in Cincinnati, Ohio, on Sunday, September 14, 2025, at 1:00 p.m. ET, airing on CBS.
Both teams aim to improve to 2-0 after Week 1 wins, with the Jaguars dominating Carolina and the Bengals scraping by Cleveland. Below, we analyze the odds, key matchups, and betting trends for this matchup.
Team Overview
Jacksonville Jaguars (1-0, 2024: 9-8)
The Jaguars controlled their Week 1 game, defeating the Panthers 26-10 with 17 points in the second quarter. They ran for 200 yards, led by Travis Etienne’s 143 yards, including a 71-yard run, while Trevor Lawrence threw for 178 yards and 1 TD. Jacksonville’s defense, anchored by LB Foyesade Oluokun (10 tackles, 1 INT), held Carolina to 10 points. Jacksonville is 8-3-1 ATS in their last 12 games but struggles on the road (1-11 SU in last 12 road games).
Key Players:
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QB Trevor Lawrence: 19/31, 178 yards, 1 TD, 1 INT in Week 1.
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RB Travis Etienne Jr.: 16 carries, 143 yards, including a 71-yard run in Week 1.
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WR Travis Hunter: Rookie dual threat debuted in Week 1, adding versatility.
Cincinnati Bengals (1-0, 2024: 9-8)
Narrowly escaping Cleveland in Week 1 with a 17-16-win, Cincinnati’s was limited to 141 yards from scrimmage. Joe Burrow struggled (14/23, 113 yards, 1 TD, 3 sacks), and Ja’Marr Chase was held to 2 catches for 26 yards. The offense managed only 11 first downs, with Chase Brown rushing for 43 yards. The Bengals are 3-6 ATS in their last nine Week 2 games, and the OVER is 6-1 in their last seven home games.
Key Players:
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QB Joe Burrow: 14/23, 113 yards, 1 TD in Week 1, sacked 3 times.
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RB Chase Brown: 21 carries, 43 yards in Week 1, capped an early drive.
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WR Ja’Marr Chase: 2 catches, 26 yards in Week 1, expected to rebound.
Key Matchups
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Jaguars’ Run Game vs. Bengals’ Run Defense:
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Jacksonville’s 200 rushing yards in Week 1, led by Etienne’s 71-yard run, faces a Bengals defense that allowed 78 rushing yards to Cleveland. The Bengals’ injuries on the offensive line (Volson on IR, Patrick questionable) may spill over to defensive adjustments.
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Burrow and Chase vs. Jaguars’ Secondary:
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Cincinnati’s passing game underperformed in Week 1 (113 yards), but Burrow and Chase could exploit Jacksonville’s secondary, which allowed 170 passing yards to Carolina. Rookie Travis Hunter’s coverage skills will be tested.
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Jaguars’ Road Struggles vs. Bengals’ Home Edge:
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Jacksonville’s 1-11 SU record in their last 12 road games contrasts with Cincinnati’s 6-1 OVER trend in recent home games, suggesting a potential for higher scoring at Paycor Stadium.
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Betting Trends
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Jaguars: 8-3-1 ATS in last 12 games, 1-4 ATS vs. AFC North opponents, 1-11 SU in last 12 road games.
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Bengals: 3-6 ATS in last nine Week 2 games, OVER 6-1 in last seven home games.
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Head-to-Head: The series is competitive, with no recent dominance noted.
Betting Analysis
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Spread: Jacksonville’s 8-3-1 ATS record shows consistency, but their 1-11 SU road record and 1-4 ATS vs. AFC North teams suggest struggles against Cincinnati’s home-field advantage (68%-win probability). The Bengals’ defense saved their Week 1 win, but offensive struggles (141 yards from scrimmage) and injuries (Volson, Patrick) raise concerns about covering a 3.5-point spread.
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Moneyline: Cincinnati’s -190 odds imply a 65.5%-win probability, supported by their home edge and Burrow’s potential to rebound. Jacksonville’s +155 reflects a 39.2% upset chance, bolstered by Etienne’s run game and Lawrence’s protection, but road woe trends limit their edge.
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Over/Under (49.5): The OVER has hit in 6 of Cincinnati’s last 7 home games, but both teams’ Week 1 games stayed UNDER (Jags 36, Bengals 33). Jacksonville relied of 4 field-goals vs. Carolina and Cincinnati’s low output could suggest a lower-scoring game as offenses still ramp up.
This Week 2 matchup between the Jaguars and Bengals features two 1-0 teams looking to forge ahead to 2-0. Jacksonville’s run-focused offense, led by Travis Etienne, faces a Bengals defense that stifled Cleveland.
Meanwhile, Cincinnati’s passing game, led by Joe Burrow and Ja’Marr Chase, is poised to rebound against Jacksonville’s secondary, featuring rookie Travis Hunter. The Bengals’ offensive explosion potential in their home opener offers an edge, while road troubles for Jacksonville tilt the odds.